Table 5.

Independent effect of gender, age, pre-existing diseases, and symptoms during SARS-CoV-2 infection on Long COVID-19 symptoms in the primary care setting

Response variable	Explanatory variables	OR (95% CI)	p-value
	Gender (Females vs Males)	1.18 (0.79–1.76)	0.421
	Age (years)
At least one Long COVID-19	0–5	1 (reference)
symptom	6–10	1.41 (0.84–2.37)	0.194
	11–16	2.18 (1.31–3.62)	0.003
(153)
	Pre-existing diseases (yes vs no)	1.11 (0.58–2.12)	0.746
	Symptomatic acute infection (yes vs no)	6.57 (4.36–9.9)	< 0.001
	Gender (Females vs Males)	1.31 (0.67–2.55)	0.424
Abnormal fatigue	Age
(44)	1–5 years	1 (reference)
	6–10	2.85 (0.87–9.34)	0.083
	11–16	7.05 (2.35–21.12)	< 0.001
	Pre-existing diseases (yes vs no)	1.52 (0.62–3.74)	0.355
	Symptomatic acute infection (yes vs no)	12.22 (5.01–29.78)	< 0.001
	Gender (Females vs Males)	1.67 (0.85–3.24)	0.132
	Age (years)
Neurological symptoms	1–5	1 (reference)
(43)	6–10	5.27 (1.47–18.94)	0.011
	11–16	8.73 (2.54–29.98)	0.001
	Pre-existing diseases (yes vs no)	0.79 (0.28–2.18)	0.646
	Symptomatic acute infection (yes vs no)	6.61 (3.13–13.94)	< 0.001
	Gender (Females vs Males)	0.98 (0.5–1.91)	0.954
	Age (years)
Respiratory symptoms	0–5	1 (reference)
(38)	6–10	0.32 (0.14–0.72)	0.006
	11–16	0.23 (0.09–0.58)	0.002
	Pre-existing diseases (yes vs no)	1.14 (0.32–4.03)	0.840
	Symptomatic acute infection (yes vs no)	2.11 (1.07–4.13)	0.030
	Gender (Females vs Males)	1.61 (0.75–3.43)	0.217
	Age (years)
Psychological symptoms	1–5	1 (reference)
(31)	6–10	1.28 (0.39–4.16)	0.682
	11–16	3.79 (1.36–10.52)	0.011
	Pre-existing diseases (yes vs no)	0.78 (0.22–2.74)	0.699
	Symptomatic acute infection (yes vs no)	3.08 (1.42–6.67)	0.004

Total number of patients = 629. Odds ratios and p-values were computed by a multivariable logistic regression model. Results on the whole sample are described in Supplementary Table 2