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. 2022 Jun 2;12(6):e056147. doi: 10.1136/bmjopen-2021-056147

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Flow diagram of Myeloma XIV (Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma) Trial. ADL, activity of daily living; HE, health economics; IADL, instrumental activity of daily living; IMWG, International Myeloma Working Group; IRD, ixazomib, lenalidomide and dexamethasone; QoL, quality of life; R+I, lenalidomide+ixazomib.