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. 2022 Mar 16;71(6):1233–1245. doi: 10.2337/db21-0992

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© 2022 by the American Diabetes Association

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Adipose tissue mass and function are improved in diabetic mice with reduced β-cell GCK. A: Representative images of epididymal/gonadal WAT and interscapular BAT. B: Quantification epididymal WAT and interscapular BAT (n = 8–15 mice/group). C and E: Representative images of paraffin sections of H-E–stained WAT and BAT. D and F: Quantitative real-time PCR analysis of adiponectin, CD36, leptin, and PPARγ for WAT or UCP-1, PPARγ, and PPARα for BAT (n = 4–13 mice/group). Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Nonsignificant differences are not shown. Ctrl, control.