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. 2022 May 31;15(6):100640. doi: 10.1016/j.waojou.2022.100640

Table 5.

Examples of antibiotic allergy assessment criterion

Author (year) Clinically validated or expert opinion Risk assessment criteria
Low risk Moderate risk High risk
Shenoy et al. (2019)21 Expert opinion
  • 1.

    Isolated reactions that are unlikely allergic (eg, GI, headaches)

  • 2.

    Pruritus without rash

  • 3.

    Remote (>10 y) unknown reactions without features of IgE

  • 4.

    Family history of penicillin allergy
  • 1.

    Urticaria or other pruritic rashes

  • 2.

    Reactions with features of IgE but not anaphylaxis
  • 1.

    Anaphylactic symptoms.

  • 2.

    Positive skin testing

  • 3.

    Recurrent reactions

  • 4.

    Reactions to multiple beta-lactam antibiotics
Devchand et al. (2019)22 Clinically validated
  • 1.

    Childhood exanthema unspecified

  • 2.

    Diffuse rash (>24 h post) > 10 years ago

  • 3.

    Unknown reaction >10 years ago or family history

  • 4.

    Isolated reactions are unlikely to be allergic (e.g. GI, headache
  • 1.

    Urticaria

  • 2.

    Angioedema

  • 3.

    Swelling

  • 4.

    Immediate onset rash (<2 h post dose)

  • 5.

    Laryngeal or respiratory involvement
  • 1.

    Anaphylaxis

  • 2.

    Blistering, pustular or desquamating rash

  • 3.

    Rash and mucosal ulceration

  • 4.

    Severe renal, liver or haematological abnormalities

  • 5.

    Unknown reaction <10 years ago