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Synthesis and structures of inhibitors of bacterial adenlylate cyclases. (A) Synthesis of bis(amidate) prodrug of adefovir. (B) Synthesis of bis(amidate) prodrug of 8-aza-7-deaza analogue of adefovir. (C) Structures of 5-aryl-4-PME-2-aminothiazoles and 4-aryl-5-PME-2-aminothiazoles.
