TABLE 1.

In- and exclusion criteria in AMEND.

Patients
Inclusion criteria
+ Antipsychotic-naïve, first-episode psychosis
+ Fulfilling diagnostic criteria of schizophrenia, persistent delusional disorder, acute and transient psychotic disorders, schizoaffective disorder, other non-organic psychotic disorders and unspecified non-organic disorders (ICD-10: F20.x; F22.x; F23.x; F24.x; F25.x; F28; and F29)
+ Age: 18–45 years
+ Legally competent
Exclusion criteria
- Current substance dependence ICD-10 (F1x.2) or substance abuse in any period up to 3 months prior to referral (exception: tobacco/nicotine, F17.2)
- Treatment with antidepressants within 30 days
- Head injury with more than 5 minutes of unconsciousness
- Any coercive measure
- Metal implanted by operation
- Pacemaker
- Pregnancy (assessed by urine HCG)
- Female patients: Unwillingness to use safe contraception (Intra Uterine Device/System or hormonal contraceptives) during the study period.
- Severe physical illness
- Allergies to any of the inactive ingredients and film coat components
Healthy controls (N = 20) matched on age and gender
Inclusion criteria
+ No first-degree relative with known major psychiatric disorder (ICD-10: F1x; F2x; and F3x)
+ Age: 18-45 years
+ Legally competent
Exclusion criteria
- Lifetime substance abuse/dependence ICD-10 (F1x.1/F1x.2) (exception: tobacco/nicotine, F17.1/F17.2)
- Head injury with more than 5 minutes of unconsciousness
- Lifetime treatment with antidepressants
- Metal implanted by operation
- Pacemaker
- Pregnancy (assessed by urine HCG)
- Females: Unwillingness to use safe contraception (Intra Uterine Device/System or hormonal contraceptives) during the study period.
- Severe physical illness