TABLE 7.

Studies that feature PTCML assessment and outcomes (48, 84–86).

References	Endpoint	Definition of PTCML	Findings	Level of evidence (grade)
Einecke et al. (84)	Graft loss	One PTC with ≥5 basement membrane layers	In non-selected transplant population, 1 PTC with ≥5 basement membrane layers predictive of graft loss in multivariate analysis (HR 1.98, p = 0.01)	Low
Roufosse et al. (85)	TG	Numbers of PTC with ≥3 and ≥5 basement membrane layers	Risk of TG increases with increasing numbers of PTC with ≥3 and ≥5 basement membrane layers	Low + 1 (‘dose–response’ gradient)
de Kort et al. (86)	Graft loss	Three PTC with ≥5 basement membrane layers	In patients with dnDSA, 3 PTC with ≥5 basement membrane layers associated with increased graft loss (p = 0.016)	Low
de Kort et al. (86)	TG	Mean basement membrane layer count >2.5	Mean PTCML count >2.5 associated with increased risk of TG (p = 0.001); progressors to >2.5 associated with more TG	Low
Dobi et al. (48)	Graft loss	PTC circ score ≥3	In patients with cAMR, PTC circ ≥3 predicts graft loss	Low

AMR, antibody-mediated rejection; c, chronic; dn, de novo; DSA, donor-specific antibody; HLA, human leukocyte antigen; HR, hazard ratio; PTC, peritubular capillary; PTCML, peritubular capillary basement membrane multilayering; TG, transplant glomerulopathy.