TABLE 3.
HR (multivariate models) for graft failure according to graft histology, renal function, and proteinuria at time of biopsy, adjusted for donor age and time after transplantation (8,9).
| Parameter | Adjusted HR (95% CI) | p value | |
|---|---|---|---|
| Naesens et al., 2016 (N = 1,335 indication biopsies) (8) | |||
| Proteinuria at time of biopsy | 0.3–1.0 vs. <0.3 g/24 h | 1.14 (0.81–1.60) | 0.50 |
| 1.0–3.0 vs. <0.3 g/24 h | 2.17 (1.49–3.18) | <0.001 | |
| >3.0 vs. <0.3 g/24 h | 3.01 (1.75–5.18) | <0.001 | |
| eGFR at time of biopsy | 30–45 vs. >45 ml/min/1.73 m2 | 1.76 (0.59–5.30) | 0.31 |
| 15–30 vs. >45 ml/min/1.73 m2 | 5.53 (1.99–15.4) | 0.001 | |
| <15 vs. >45 ml/min/1.73 m2 | 11.7 (4.17–33.0) | <0.001 | |
| Microcirculation inflammation | g + ptc ≥2 vs. <2 | 1.36 (0.97–1.91) | 0.07 |
| IFTA grade | Banff grade 1 vs. 0 | 1.82 (1.25–2.64) | 0.002 |
| Banff grade 2–3 vs. 0 | 3.45 (2.34–5.07) | <0.001 | |
| Transplant glomerulopathy | Banff grade 1 vs. 0 | 1.00 (0.55–1.82) | 0.99 |
| Banff grade 2–3 vs. 0 | 1.83 (1.11–3.04) | 0.02 | |
| De novo/recurrent glomerular disease | Present vs. absent | 1.35 (0.84–2.19) | 0.22 |
| Polyomavirus-associated nephropathy | Present vs. absent | 5.51 (3.06–9.92) | <0.001 |
| Loupy et al., 2019 (N = 3,941 patients) (9) | |||
| Time from transplant to evaluation (years) | 1.08 (1.02–1.14) | 0.0051 | |
| eGFR (mL/min/1.73 m2) | 0.96 (0.95–0.96) | <0.0001 | |
| Proteinuria (log) | 1.51 (1.40–1.63) | <0.0001 | |
| IFTA | 0/1 | — | |
| 2 | 1.14 (0.918–1.424) | ||
| 3 | 1.39 (1.083–1.773) | 0.0311 | |
| Microcirculation inflammation (g + ptc) | 0–2 | — | |
| 3–4 | 1.45 (1.121–1.876) | ||
| 5–6 | 1.83 (1.240–2.706) | 0.0010 | |
| Interstitial inflammation and tubulitis (i + t) | 0–2 | — | |
| ≥3 | 1.34 (1.061–1.684) | 0.0136 | |
| Transplant glomerulopathy (cg) | 0 | ||
| ≥1 | 1.47 (1.133–1.895) | 0.0036 | |
| Anti–HLA-DSA MFI | <500 | — | |
| ≥500 to 3,000 | 1.25 (0.965–1.606) | ||
| ≥3,000 to 6,000 | 1.72 (1.115–2.659) | ||
| ≥6,000 | 2.05 (1.472–2.860) | 0.0001 | |
cg, transplant glomerulopathy; CI, confidence interval; DSA, donor-specific antibodies; eGFR, estimated glomerular filtration rate; g, glomerulitis score; HLA, human leukocyte antigen; HR, hazard ratio; i, interstitial; IFTA, interstitial fibrosis and tubular atrophy; MFI, mean fluorescence intensity; ptc, peritubular capillaritis score; t, tubulitis score.