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PK/PD parameter estimates for the AUC0−24h/MIC index and AUC0−24h/MIC values required for various antibacterial effects.
| Parameter | Colistin | Colistin/IBG |
|---|---|---|
| E0 (log10CFU/lung) | 0.51 | 0.41 |
| Imax (log10CFU/lung) | 4.55 | 5.85 |
| IC50 | 122.19 | 619.45 |
| AUC0−24h/MIC for bacteriostatic action | 15.62 | 47.55 |
| AUC0−24h/MIC for 1 log10 kill | 60.66 | 197.70 |
| AUC0−24h/MIC for 2 log10 kill | 150.15 | 435.44 |
| AUC0−24h/MIC for 3 log10 kill | – | 865.87 |
| AUC0−24h/MIC for 4 log10 kill | – | 1894.39 |
