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. 2022 May 20;12:765768. doi: 10.3389/fphar.2021.765768

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Copyright © 2022 Lu, Wang, Ye, Feng, Liu, Xu, Wang, Zhang, Liu, Zhao, Xu, Ye and Wan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of CXC Chemokines in atherosclerosis.Chemokines mainly control the migration of neutrophils, monocytes, T cells, smooth muscle progenitor cells and angiogenic cells in atherosclerosis. CXCL1 and CXCL8 recruit neutrophils through the PI3K / AKT pathway and plays a pro-inflammatory role. CXCL4 forms heterodimers with CCL5 to recruit monocytes. CXCL9, CXCL10 and CXCL11 recruit T cells through STAT3, STAT6 pathway, exacerbating tissue inflammation. And CXCL12 recruits smooth muscle progenitor cells, angiogenic cells and inflammatory cells, which also plays a pro-inflammatory role and a protective role. In addition, CXCL16 recruits T cells and acts as an oxLDL clearance receptor.