Table 3.

Effects of STG, STG/Mn, and STG/Co on liver function levels in male rats.

Parameters	Control	STG	STG/Mn	STG/Co
ALT (U/L)	12.51 ± 0.42 c (−−−)	123.31 ± 6.69 a (++++)	13.40 ± 0.82 bc (−−−)	23.87 ± 3.14 b (−−−)
AST (U/L)	12.43 ± 0.37 c (−−−)	164.26 ± 5.27 a (++++)	11.27 ± 0.52 c (−−−)	25.53 ± 3.20 b (−−−)
LDH (U/L)	84.05 ± 8.47 c (−−−)	567.42 ± 47.00 a (++++)	133.56 ± 11.91 c (−−−)	220.02 ± 12.05 b (++−)

Results are expressed as mean ± SE. Symbols are different alphabetically to indicate a significant comparison compared to the control group and other treated groups (p < 0.05) (Similar letters imply partial or complete nonsignificance). STG, Sitagliptin; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; LDH, Lactate dehydrogenase. Scoring of hepatic enzymes: (++++), moderate hepatic damage; (++−), slight hepatic damage; and (−−−), no hepatic damage.