Table 4.
Effects of STG, STG/Mn, and STG/Co on oxidative stress enzymes and oxidative damage markers in hepatic tissues in male rats.
| Parameters | Control | STG | STG/Mn | STG/Co |
|---|---|---|---|---|
| CAT (U/g) | 7.68 ± 0.26 b | 1.79 ± 0.16 c | 7.00 ± 1.11 a | 6.87 ± 0.35 b |
| SOD (U/g) | 8.19 ± 0.26 b | 2.07 ± 0.45 d | 7.83 ± 0.34 a | 7.86 ± 0.39 c |
| GRx (U/g) | 6.46 ± 0.38 a | 1.30 ± 0.88 c | 6.12 ± 0.33 a | 6.09 ± 0.45 b |
| MDA (µg/mg) | 2.75 ± 0.15 c | 55.21 ± 1.30 a | 5.71 ± 0.68 b | 4.64 ± 0.68 b |
| GPx (U/g) | 12.22 ± 0.45 a | 2.55 ± 0.40 c | 11.72 ± 0.51 a | 11.56 ± 0.65 b |
Results are expressed as mean ± SE. Symbols are different alphabetically to indicate a significant comparison compared to the control group and other treated groups (p < 0.05) (Similar letters imply partial or complete nonsignificance). Similar letters imply partial or complete nonsignificance. STG, Sitagliptin; CAT, Catalase; MDA, Malondialdehyde; SOD, Super oxide dismutase; GRx, Glutathione reductase; and GPx, Glutathione peroxidase.