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Circulating levels of kidney dysfunction. Increased levels of circulating biomarkers of renal dysfunction including creatinine, blood urea nitrogen (BUN), and symmetric dimethylarginine (SDMA) as assessed in the end-of-life samples. Data are presented as Mean ± SEM and BUN and creatinine (n = 10 Con; n = 10 CKD; * p < 0.05). For SDMA the data are also presented as Mean ± SEM but n = 5 (Con) and n = 4 (CKD; * p < 0.05).
