Figure 2.

Bar charts with one standard error show supernatant levels of tumor necrosis factor (TNF)-α, interleukin (IL)-10, and IL-12 from peripheral blood mononuclear cells (PBMCs) with and without lipopolysaccharide (LPS) stimulation and anti-S100A12 treatment. Productions of TNF-α, IL-10, and IL-12 from PBMCs were significantly increased after LPS stimulation in both controls and patients with sepsis. Additional anti-S100A12 monoclonal antibodies increased the production of TNF-α and IL-10 in LPS-stimulated PBMCs from both controls and patients.