Table 2.
Plasma AGE, sRAGE, and HMGB1 levels (mean ± standard error mean) on Days 1 and 7 in survivors, non-survivors, and controls.
| Survivors | Non-Survivors | All Patients | Controls | |
|---|---|---|---|---|
| Day 1 | (n = 30) | (n = 14) | (n = 44) | (n = 27) |
| AGE, ng/mL | 4335.9 ± 1249.4 | 3839.5 ± 1715.1 | 4177.9 ± 1001.0 | 2117.8 ± 833.4 |
| sRAGE, pg/mL | 2355.2 ± 314.9 | 2751.5 ± 650.0 | 2481.3 ± 295.0 | 1273.0 ± 108.2 * |
| HMGB1, pg/mL | 306.3 ± 86.1 | 247.4 ± 56.8 | 287.6 ± 61.1 | 160.7 ± 54.0 |
| S100A12, pg/mL | 533.4 ± 20.2 | 523.6 ± 38.8 | 530.3 ± 18.2 | 310.1 ± 28.1 * |
| Day 7 | (n = 29) | (n = 5) | (n = 34) | |
| AGE, ng/mL | 5372.0 ± 1254.3 | 10517.0 ± 6020.9 | 6128.7 ± 1373.1 | |
| sRAGE, pg/mL | 1530.1 ± 219.1 | 1041.6 ± 371.9 | 1458.2 ± 195.2 | |
| HMGB1, pg/mL | 324.6 ± 88.1 | 271.0 ± 114.0 | 316.7 ± 76.6 | |
| S100A12, pg/mL | 499.3 ± 23.8 | 593.1 ± 12.7 † | 513.1 ± 21.1 |
Abbreviations: AGE, advanced glycation end products; sRAGE, soluble receptor for AGE; HMGB1, high-mobility group box 1. * p < 0.001 compared with all patients with sepsis by independent-samples t-test; † p = 0.002 compared with survivors by independent-samples t-test.