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. 2022 Jun 3;144(2):377–379. doi: 10.1007/s00401-022-02442-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b MRI susceptibility weighted imaging (SWI) reveals a subinsular hemorrhage (red circles) 26 days after onset of symptoms. c, d Hematoxylin and eosin (HE) of a biopsy from the left caudate nucleus shows strong lymphocytic infiltrates (c, scale bar 20 μm) and astrocytes with eosinophilic intranuclear inclusion bodies (d, scale bar 10 μm). e, f In autoptic material, the hemorrhage with surrounding macrophages was seen (e, HE, scale bar 50 µm). Strikingly, a positive immunoreaction for BoDV-1 was detected in components of vessels (white arrow) and endfeet of astrocytes (black arrow) (f, scale bar 20 µm). g Electron microscopy shows two infected endothelial cells (yellow) with replication centers (grey arrows). For orientation, tight junctions (black arrow) and basal membranes (white arrows) are marked (scale bar 2 µm). h Higher magnification view of g (area within rectangle) displays detailed architecture of a viral replication center (arrow; scale bar 200 nm)