TABLE 3.

Subgroup analyses of high ratios of n-6/n-3 PUFAs and risk of depression (highest vs. lowest category).

Subgroup	No. of studies	Odds risk (95% CI)	I2%	P value
Regions:
America	4	1.44 (1.24∼1.67)	0.00	0.19
Asia	3	1.29 (1.07∼1.56)	0.00	0.72
Europe	4	0.94 (0.82∼1.07)	0.00	0.88
Population:
Pregnant women	5	1.53 (1.10∼2.13)	36.46	0.19
Healthy people	6	1.12 (0.94∼1.32)	56.53	0.03
Covariate method:
Adjustment for age	8	1.15 (0.99∼1.33)	53.18	0.03
No adjustment for age	3	2.24 (1.40∼3.59)	0.00	0.50
Adjustment for BMI	7	1.20 (1.02∼1.40)	22.39	0.45
No adjustment for BMI	4	1.39 (0.96∼2.01)	82.56	0.00
Adjustment for energy	2	1.26 (0.97∼1.65)	22.58	0.26
No adjustment for energy	9	1.22 (1.01∼1.47)	59.93	0.01
Adjustment for education	4	1.07 (0.84∼1.36)	61.91	0.03
No adjustment for education	7	1.32 (1.11∼1.57)	32.47	0.13
Adjustment for smoking	7	1.11 (0.95∼1.30)	51.46	0.05
No adjustment for smoking	4	1.72 (1.18∼2.52)	34.37	0.23
Adjustment for drinking	4	1.07 (0.86∼1.35)	53.31	0.06
No adjustment for drinking	7	1.33 (1.10∼1.63)	43.59	0.09
Risk expression
Hazard/rate ratio	2	1.10 (0.73∼1.65)	88.73	0.00
Odds ratio	7	1.27 (1.02∼1.58)	38.82	0.11
Relative risk	2	1.32 (1.09∼1.59)	0.00	0.37
Quality assessment
High	6	1.17 (0.99∼1.37)	58.12	0.02
Moderate	5	1.49 (0.91∼2.43)	61.58	0.05