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. 2022 May 19;48(1):125. doi: 10.3892/or.2022.8336

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Copyright: © Deng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Targeting PBK with HI-TOPK-032 induces the apoptosis of D341 cells in vitro. (A and B) The percentage of apoptotic cells was significantly increased in the HI-TOPK-032-treated D341 cells. Scale bar, 100 µm. Quantitative results are presented as the mean ± SD. Statistical significance according to an unpaired Student's t-test is indicated: *P<0.05. (C) Western blot analysis revealed that the level of cleaved caspase-3 in D341 cells was substantially increased following treatment with HI-TOPK-032.