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Model of “double fork failure” and “break-induced replication”. Under replication stress, both of the replication forks at CFSs stall, namely “double fork failure”, and CFSs remain under-replicated before mitosis. In prometaphase, both of the stalled forks are cleaved by MUS81-EME1 complex, giving rise to the DSB formation. Thereafter, two head-on forks restart replication through BIR, which is dependent on POLD3 and RAD52.
