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The therapeutic effect of berberine on Alzheimer’s disease. Berberine inhibits Aβ aggregation, tau hyperphosphorylation and pro-inflammatory cytokines production, in addition to regulating glutathione metabolism pathways and mitochondrial bioenergetics. SOCS1, suppressor of cytokine signaling 1; Aβ, amyloid β; BACE1, beta-secretase 1; p-ERK, phosphorylated extracellular signal-regulated kinase.
