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Remimazolam mediated hyper-phosphorylation of tau proteins in mouse brain. (a) Significant depositions of amyloid β plaque in remimazolam treated mice group assessed by immunohistochemistry. (b) Remimazolam significantly induced the activation of tau protein and phosphorylated tau in mouse brain, compared to control. Right panel shows the quantifications. Quantifications of protein levels. Experiments (n = 3). Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.
