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Remimazolam induced glutamate excitotoxicity by increasing Ca2+ influx. (a) Remimazolam increased expression of glutamate receptor NMDA or AMPA receptors. (b) Remimazolam mediated increased calcium influx in treated mice. (c) Remimazolam induced activation of CAMKII in treated groups. Quantifications of protein levels. Experiments (n = 3). Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.
