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Effect of aza-T-dCyd and aza-dCyd on tumor growth and DMNT1 levels in CEM tumor xenografts. Mice bearing CEM tumor xenografts were treated daily for 9 days with either 1 mg/kg aza-T-dCyd or 0.5 mg/kg aza-dCyd. Treatment with 0.5 mg/kg aza-dCyd daily for 9 days resulted in the death of all mice. After a 3-day rest period, aza-T-dCyd treatment was resumed for another 20 days. At the end of the 20-day treatment period the mice were sacrificed, and DNMT1 levels in tumor were determined.
