TABLE 1.
Toxicity and DNMT1 depletion in CEM tumor xenografts in mice
post-treatment with either aza-T-dCyd or aza-dCyd
Mice bearing CEM tumor xenografts were treated daily for 9 days with either aza-T-dCyd or aza-dCyd (0.3–5 mg/kg per dose). At death of animal or day 10, tumors were removed and evaluated for DNMT1 (Thottassery et al., 2014).
| Dose (mg/kg × 9) |
Aza-T-dCyd | Aza-dCyd | ||
|---|---|---|---|---|
| DNMTI | Death | DNMTI | Death | |
| 5 | ND | No | ND | Yes |
| 2.5 | ND | No | ND | Yes |
| 1.2 | ND | No | ND | Yes |
| 0.6 | ND | No | ND | Yes |
| 0.3 | ± | No | ± | No |
| ND, DNMT1 not detected; ±, DNMT1 barely detected | ||||