. Author manuscript; available in PMC: 2022 Jun 4.

Published in final edited form as: J Bone Miner Res. 2020 Jul 12;35(10):2070–2081. doi: 10.1002/jbmr.4110

Table 1:

Biochemical analysis of plasma/serum from Ank^+/+ and Ank^KI/KI mice

Tests	Samples	0.3% Pi diet		0.7% Pi diet
Tests	Samples	Ank ^+/+	Ank ^KI/KI	Ank ^+/+	Ank ^KI/KI
PPi	plasma	N/A	N/A	1.52±0.22 (n=10)	1.02±0.26^* (n=12)
Pi	serum	6.19±1.34 (n=25)	6.05±0.84 (n=20)	6.40±0.51 (n=15)	6.20±1.04 (n=13)
Ca	serum	9.40±0.43 (n=25)	9.20±0.40 (n=20)	9.77±0.69 (n=15)	9.21±0.95 (n=13)
PTH	serum	91.28±52.65^# (male, n=14)	150.7±121.10 (male, n=12)	301.94±216.65 (male, n=12)	259.69±122.82 (male, n=10)
		245.83±231.13 (female, n=11)	192.03±138.72 (female, n=8)	147.44±111.62 (female, n=3)	133.26±93.35 (female, n=3)
25OHD	serum	41.95±7.76^# (male, n=10)	36.68±12.12 (male, n=10)	55.52±12.88 (male, n=10)	46.25±15.05 (male, n=4)
		47.41±8.49 (female, n=11)	46.56±9.08 (female, n=8)	57.92±5.77 (female, n=3)	53.59±4.07 (female, n=3)

PPi (μM); Pi (mg/dl); Ca (mg/dl); Intact PTH (pg/ml); 25OHD: 25-hydroxy vitamin D (ng/ml); Data are mean ± SD. p < 0.05 is indicated by:

^(*)

significant difference between Ank^+/+ and Ank^KI/KI mice fed with the same diet;

^(#)

significant difference between normal and Pi diet in mice with the same genotype. Data for serum PPi, Pi, Ca were combined from male and female mice. Male and female mice showed the same pattern of PPi, Pi and Ca levels.