Table 2.
Major regimens used in NK/T-cell lymphomas, listed in alphabetical order according to acronyms
| Regimens | Drugs and schedule | References |
|---|---|---|
| AspaMetDex | E. coli L-asparaginase: 6000 U/m2, IM, days 2, 4, 6, 8 | [73] |
| Methotrexate: 3000 mg/m2, IV, day 1 | ||
| Dexamethasone: 40 mg, oral, days 1–4 | ||
| DDGP | Dexamethasone: 15 mg/m2, IV, days 1–5 | [76] |
| Cisplatin: 20 mg/m2, IV, days 1–4 | ||
| Gemcitabine: 800 mg/m2, IV, days 1, 8 | ||
| Pegaspargase: 2500 IU/m2, IM, day 1 | ||
| DeVIC (2/3) | Dexamethasone: 40 mg, IV, days 1–3 | [57] |
| Etoposide: 67 mg/m2, IV, days 1–3 | ||
| Ifosfamide: 1000 mg/m2, IV, days 1–3 | ||
| Carboplatin: 200 mg/m2, IV, day 1 | ||
| DICE-L-asp | Dexamethasone: 20 mg/m2, days 1–4 | [69] |
| Ifosfamide: 1200 mg/m2, IV, days 1–3 | ||
| Cisplatin: 25 mg/m2, IV, days 1–4 | ||
| Etoposide: 60 mg/m2, days 1–4 | ||
| L-asparaginase: 6000 U/m2, days 6–11 | ||
| GELAD | Gemcitabine: 1000 mg/m2, IV, day 1 | [70] |
| Etoposide: 60 mg/m2, IV, days 1–3 | ||
| Pegaspargase: 2000 U/m2, day 5 | ||
| Dexamethasone: 40 mg, days 1–4 | ||
| GELOX | Gemcitabine: 1000 mg/m2, IV, days 1, 8 | [66] |
| E. coli L-asparaginase: 6000 U/m2, IM, days 1–7 | ||
| Oxaliplatin: 130 mg/m2, IV, day 1 | ||
| LVP | L-asparaginase: 6000 IU/m2, IV, days 1–5 | [63] |
| Vincristine: 1.4 mg/m2, IV, day 1 | ||
| Prednisolone: 100 mg, oral, days 1–5 | ||
| MEDA | Methotrexate: 3000 mg/m2, IV, day 1 | [74] |
| Etoposide: 100 mg/m2, IV, days 2–4 | ||
| Dexamethasone: 40 mg, IV, days 2–4 | ||
| Pegaspargase: 2500 U/m2, day 4 | ||
| MESA | Methotrexate: 1000 mg/m2, IV, day 1 | [30] |
| Etoposide: 100 mg/m2, days 2–4 | ||
| Dexamethasone: 40 mg, IV, days 2–4 | ||
| Pegaspargase: 2500 U/m2, IM, day 4 | ||
| P-GEMOX | Pegaspargase: 2500 IU/m2, IM, day 1 | [67] |
| Gemcitabine: 1000 mg/m2, IV, days 1, 8 | ||
| Oxaliplatin: 130 mg/m2, IV, day 1 | ||
| SMILE | Dexamethasone: 40 mg, IV or oral, days 2–4 | [62] |
| Methotrexate: 2000 mg/m2, IV, day 1 | ||
| Ifosfamide: 1500 mg/m2, IV, days 2–4 | ||
| E. coli L-asparaginase: 6000 U/m2, IV, days 8, 10, 12, 14, 16, 18, 20 | ||
| Etoposide: 100 mg/m2, IV, days 2–4 | ||
| VIDL | Etoposide: 100 mg/m2, IV, days 1–3 | [60] |
| Ifosfamide: 1200 mg/m2, IV, days 1–3 | ||
| Dexamethasone: 40 mg, IV, days 1–3 | ||
| L-asparaginase: 4000 IU/m2, IM, days 8, 10, 12, 14, 16, 18, 20 | ||
| VIPD | Etoposide: 100 mg/m2, IV, days 1–3 | [59] |
| Ifosfamide: 1200 mg/m2, IV, days 1–3 | ||
| Cisplatin: 33 mg/m2, IV, days 1–3 | ||
| Dexamethasone: 40 mg, IV or oral, days 1–4 |
IV: intravenous, IM: intramuscular; doses given are daily dosages