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. 2022 Jun 3;41:193. doi: 10.1186/s13046-022-02396-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — S100A8 and S100A9 are greatly expressed in primary breast tumors and correlate with poor clinical outcomes. A TNM box plot of S100A8 gene expression in normal and breast tumor tissues. B TNM box plot of S100A9 gene expression in normal and breast tumor tissues. C Kaplan-Meier Plotter Overall Survival (OS) (n = 1879) and Relapse Free Survival (RFS) (n = 4929) analysis in breast cancer subtypes harboring low and high levels of S100A8, respectively, at a follow up threshold of 180 months. Log-rank p-value is indicated within the boxes. All possible cutoff values between the lower and upper quartiles were automatically computed (i.e., auto select best cutoff on the website). Cutoff values used in the analysis were as follows: S100A8-OS: 3285; S100A8-RFS: 639. D Kaplan-Meier Plotter Overall Survival (OS) (n = 1879) and Relapse Free Survival (RFS) (n = 4929) in breast cancer subtypes harboring low and high levels of S100A9, respectively, at a follow up threshold of 180 months. Log-rank p-value is indicated within the boxes. All possible cutoff values between the lower and upper quartiles were automatically computed (i.e., auto select best cutoff on the website). Cutoff values used in the analysis were as follows: S100A9-OS: 2293; S100A9-RFS: 278