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. 2022 Jun 3;41:193. doi: 10.1186/s13046-022-02396-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Hippo pathway is significantly enriched in high RAGE expression breast cancer cohort. A Differentially expressed genes (DEGs) between high (Z-score > 1) and low (Z-score ≤ 1) RAGE expression groups in breast cancer and estimation of GSEA Hallmark in DEGs using cBioportal and Webgestalt programs. B Putative significant pathways identified among the high RAGE (Z-score > 1) expression breast cancer group as indicated by the KEGG pathway analysis for the predicted TF genes based on the DEGs. C Volcano plot for TF genes prediction by Enrichr program in high RAGE (Z-score > 1) expression breast cancer cohort. The Volcano plot shows the significance of each potential TF gene predicted by Enrichr program based on the position weight matrices from JASPAR & TRANSFAC databases. The x-axis measures the odds ratio (0, inf) calculated for the TF genes, while the y-axis gives the -log10 (p-value) of the TF genes. Larger blue points represent significant TF genes (p-value < 0.05); smaller gray points represent non-significant TF genes. The darker blue color points means the highest significance. D Venn diagram of the shared up-regulated genes by TEAD2 and TEAD4 Hippo pathway TFs in high RAGE (Z-score > 1) expression breast cancer cohort. E Gene Expression Profiling Interactive Analysis (GEPIA) box plot of FLNA expression levels in TNBC, Luminal-A and Luminal-B breast cancer subtypes