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. 2022 Jun 3;25(7):104528. doi: 10.1016/j.isci.2022.104528

Figure 2.

Figure 2

VE607 inhibits infection of SARS-CoV-1 and SARS-CoV-2 pseudoviral particles and of authentic SARS-CoV-2

(A) VE607 inhibition of SARS-CoV-1, SARS-CoV-2, or VSV-G (specificity control) pseudovirus.

(B) VE607 inhibition of authentic live SARS-CoV-2 virus.

(C) VE607 and the three different enantiomers are not toxic on 293T-ACE2 (left) or Vero-E6 (right) cells, as measured by CellTiter-Glo One Solution Assay for the quantitation of ATP presented in live cells.

(D) Pseudovirus neutralization of SARS-CoV-2 S mutants predicted by our in silico analysis to modulate the inhibition by VE607. Data represents the average of at least four independent experiments ± SEM.