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. 2022 Jun 2;23:41. doi: 10.1186/s12863-022-01059-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — TP53 and its associated genes are upregulated in MYCN-amplified paediatric neuroblastoma patients. a Box plots showing the relative TP53 expression levels in paediatric neuroblastoma patients with or without MYCN amplification. b Box plots show the relative TP53 signalling pathway enrichment score in paediatric neuroblastoma patients with or without MYCN amplification. c Heatmaps demonstrating the different expression levels of TP53, CCNE1, CDK2, CHEK2 and SESN1 in paediatric neuroblastoma patients with or without MYCN amplification in the TARGET, E-MTAB-161, E-MTAB-1781, E-MTAB-8248, E-TABM-38, GSE16476, GSE49710 and GSE85047 datasets