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. 2022 Jun 2;23:41. doi: 10.1186/s12863-022-01059-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Synergistic prognostic effects of CCNE1 with age at diagnosis in neuroblastoma. a Box plots showing the relative CCNE1 mRNA expression levels in paediatric neuroblastoma patients with an age at diagnosis ≥ 18 months or < 18 months in the TARGET, E-MTAB-161, E-MTAB-1781, E-MTAB-8248, E-TABM-38, GSE16476, GSE49710 and GSE85047 datasets. b Paediatric neuroblastoma patients were divided into four subgroups based on the expression levels of CCNE1 and age of diagnosis. Different overall survival rates of paediatric neuroblastoma patients in each subgroup were determined