Fig. 6.

GART inhibition abrogates germinal center plasmablast output in tonsillar organoids. A Day 7 plasmablast frequencies from untreated or lometrexol-treated tonsillar organoids from a representative tonsil donor. B Plasmablast frequency diminishment in day 7 lometrexol drugged organoids relative to untreated counterparts from three tonsil donors. *P ≤ 0.05. C B and T cell viability and TFH frequency from these same experiments. Data from each donor are depicted separately