Fig. 1.

Heatmaps of differentially methylated regions (DMRs) in the control, nonalcoholic fatty liver disease (NAFLD), viral hepatitis, and hepatocellular carcinoma (HCC) datasets. Average values of topological overlap measures for the CpG matrix combining two different DMRs were calculated as described in the “Methods” section. Heatmaps of 610 DMRs were constructed using the German control, Japanese NAFLD, American NAFLD, Japanese viral hepatitis, Japanese HCC, and Italian HCC datasets. The order of the DMRs was the same in each of the six heatmaps. Light colors represent low topological overlap with the progressively darker red color indicating increasing overlap