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. 2022 Jun 2;22:278. doi: 10.1186/s12876-022-02360-4

Fig. 4.

Fig. 4

Differentially methylated regions (DMRs) of genes, FABP1, SGK2, and HNF4A in cirrhotic livers, and livers from patients with hepatocellular carcinoma (HCC), and HCC cell lines. Data are expressed as mean ± standard deviation. Data were analyzed using the GSE60753 dataset. The upper panels show a comparison of liver samples from control patients, patients with HCV-infected cirrhosis, and patients with HCC. The middle panels show a comparison of liver samples from control patients, patients with alcoholic cirrhosis, and patients with HCC arising from chronic alcoholism. The lower panels show a comparison between normal liver tissues and HCC cell lines. P values were calculated using Hotelling’s T-squared test