Fig. 8.

DYRK1A promotes EMT by activating a cooperative STAT3/SMAD gene transcription program. a HCC cells were incubated with DYRK1A siRNA or negative control siRNA for 48 h, and an immunofluorescence assay was then performed. b The interaction of STAT3 and SMAD2/3 in empty vector and DYRK1A overexpression group. c HCC cells were transfected with DYRK1A siRNA or the STAT3 overexpression plasmid for 48 h, and western blot analysis was then performed