TABLE III. Trypanosoma cruzi recombinant proteins/synthetic peptides for rapid diagnostics tests and epidemiological studies.
Applications | Antigen name | Corresponding protein |
Acute / congenital infections | SAPA / TCNA / TS | Trans-sialidases family |
Acute /Chronic infections | Ag36 / JL9 / MAP | Microtubule-associated protein |
Chronic infection | B13 / Ag2 / TCR39 / PEP2 / TSSA | Trypomastigote surface protein |
CRA / Ag30 / JL8 / TCR27 | Cytoplasmatic antigen | |
FRA / Ag1 / JL7 / H49 | Cytoskeleton-associated protein | |
FcaBP / 1F8 / Tc-24 / Tc-28 | Flagellar Ca++ binding protein | |
TcE / JL5 / TcP0 | Ribosomal proteins | |
cy-hsp70 / mt-hsp70 / grp-hsp78 | Heat shock proteins | |
FL160 / CEA / CRP | Flagellum-associated surface protein protein | |
SAPA, Ag 1, 2, 13, 30, 36, KMP11, HSP70, PFR2, Tgp63 | Antigens used in grouped panels |
CRA: cytoplasmatic repetitive antigen; FRA: flagellar repetitive antigen; MAP: microtubule associated protein; SAPA: shed acute-phase antigen; CEA: chronic axoantigen; CRP: complement regulatory protein; cy-hsp: cytoplasmatic heat shock protein; grp-hsp: endoplasmatic reticulum heat shock protein; mt-hsp: mitochondrion heat shock protein; TCNA: Trypanosoma cruzi neuraminidase; TS: trans-sialidase; TSSA: trypomastigote small surface antigen. Several different antigen names given to identical or similar recombinant antigens or peptides are grouped as x/y/z.