Figure 5.

in vivo efficacy study of selected compounds in a Pan02 syngeneic model of pancreatic cancer. (A) Mice (n = 5 per group) were inoculated s.c. with Pan02 cells. When tumors reached approximately 100 mm³ mice were randomized into 5 groups and treated with vehicle or compounds 20 (7.5 mg/kg, i.p.), 21 (15 mg/kg, i.p.), 27 (2.5 mg/kg, i.p.) and 23 (10 mg/kg, po) daily for 28 days. Tumor volume (mean + SEM) was monitored for each group of mice twice a week during 28 days of compound dosing. (B) No significant loss in body weight was observed during treatment.