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. Author manuscript; available in PMC: 2022 Jun 4.
Published in final edited form as: J Med Chem. 2022 Feb 15;65(4):3404–3419. doi: 10.1021/acs.jmedchem.1c01934

Scheme 3. Synthetic Route for Sulfones.

Scheme 3.

Reagents and conditions: a) i. LiOH, THF, H2O, rt; ii. 4,4-difluoropiperidine, HATU, DIEA, DMF, rt, 91%; b) RSH, Pd2(dba)3, XantPhos, DIEA, dioxane, reflux, 39-90%; c) mCPBA, DCM, rt, 35-68%.