Table 2.
Median values and 25 to 75 percentile ranges for the asymmetry-based (AB_APTw) and fluid-suppressed (FS_APTw) normalized CEST metrics, for the various glioma groups and subgroups
| Metric | IDH-wild- type Median (25–75 %tiles) |
IDH-mutant Median (25–75 %tiles) |
IDH-mutant_1p/19qret Median (25–75 %tiles) |
IDH-mutant_1p/19qcodel Median (25–75 %tiles) |
IDH-mutant_1p/19qret with AB/FS mismatch Median (25–75 %tiles) |
IDH-mutant_1p/19qret without AB/FS mismatch Median (25–75 %tiles) |
|---|---|---|---|---|---|---|
| AB_APTw (∆3.5) | 1.13 (0.79–1.37) | 1.04 (0.84–1.61) | 1.48 (0.96–1.77) | 0.99 (0.61–1.06) | 1.67 (0.97–1.82) | 1.02 (0.76–1.51) |
| FS_APTw (∆3.5) | 1.07 (0.79–1.32) | 1.03 (0.80–1.48) | 1.33 (0.90–1.65) | 0.98 (0.61–1.03) | 1.47 (0.94–1.68) | 1.00 (0.76–1.48) |
| AB_APTw (∆2) | 0.59 (0.48–0.75) | 0.95 (0.61–1.13) | 1.06 (0.92–1.40) | 0.64 (0.49–0.85) | 1.19 (0.97–1.50) | 0.72 (0.38–1.09) |
| FS_APTw (∆2) | 0.56 (0.48–0.75) | 0.73 (0.54–0.99) | 0.90 (0.63–1.10) | 0.59 (0.46–0.64) | 0.96 (0.78–1.21) | 0.63 (0.38–1.03) |
| AB_APTw ratio | 1.74 (1.59–2.08) | 1.30 (1.07–1.53) | 1.26 (1.10–1.52) | 1.34 (1.03–1.62) | 1.21 (1.00–1.39) | 1.52 (1.19–1.87) |
| FS_APTw ratio | 1.90 (1.68–2.08) | 1.45 (1.22–1.63) | 1.44 (1.29–1.62) | 1.44 (1.04–1.65) | 1.38 (1.14–1.58) | 1.52 (1.31–1.98) |
| AB-FS (∆3.5) | 0.003 (0–0.048) | 0.032 (0.01–0.12) | 0.08 (0.02–0.14) | 0.010 (0.000–0.028) | 0.12 (0.08–0.20) | 0.018 (0–0.022) |
| AB-FS (∆2) | 0.015 (0.005–0.078) | 0.12 (0.06–0.23) | 0.20 (0.09–0.24) | 0.07 (0.00–0.11) | 0.22 (0.19–0.38) | 0.069 (0–0.086) |
| AB-FS_ratio | − 0.05 (− 0.18–− 0.04) | − 0.14 (− 0.22–− 0.07) | − 0.15 (− 0.24–− 0.12) | − 0.11 (− 0.16–0) | − 0.19 (− 0.26–− 0.14) | − 0.08 (− 0.13–− 0.01) |
∆3.5 = [3–4 ppm] = 1-ppm frequency range centred on the amide frequency at 3.5 ppm; ∆2 = [1.5–2.5 ppm] = 1-ppm frequency range centred on the amine frequency at 2 ppm; AB_APTw (∆ω) asymmetry-based CEST metric in the ∆ω range (∆ω = ∆3.5 or ∆ω = ∆2) normalized to the normal appearing white matter; FS_APTw (∆ω) = fluid-suppressed CEST metric in the ∆ω range (∆ω = ∆3.5 or ∆ω = ∆2) normalized to the normal appearing white matter;. AB_APTw ratio = AB_APTw (∆3.5)/AB_APTw (∆2); FS_APTw ratio = FS_APTw (∆3.5)/FS_APTw (∆2); AB-FS = AB_APTw − FS_APTw