Table 3.

Sign test estimates of the differences between AB and FS CEST models for all the investigated metrics: amide signal, amine signal, signal ratio for amides/amines

Group	Metric
	AB-FS (∆3.5) Median (25–75 %tile) p-value	AB-FS (∆2) Median (25–75 %tile) p-value	AB-FS_ratio Median (25–75 %tile) p-value
NAWM	0.0 (0.0–0.0) 1.0	0.0 (0.0–6.2e-06) 0.21	-
IDH-wild-type	0.003 (0–0.048) 0.29	0.015 (0.005–0.078) 0.0078	− 0.05 (− 0.18–− 0.04) 0.0078
IDH-mutant	0.032 (0.01–0.12) < 0.0001	0.12 (0.06–0.23) < 0.0001	− 0.14 (− 0.22–− 0.07) < 0.0001
IDH-mutant_1p/19qret	0.08 (0.02−0.14) < 0.0001	0.20 (0.09–0.24) < 0.0001	− 0.15 (− 0.24–− 0.12) < 0.0001
IDH-mutant_1p/19qcodel	0.010 (0.0–0.028) 0.0063	0.07 (0.0–0.11) 0.0018	− 0.11 (− 0.16–− 0.01) 0.0001
IDH-mutant_1p/19qret with AB/FS mismatch	0.11 (0.08–0.20) 0.0001	0.22 (0.19–0.38) 0.0001	− 0.19 (− 0.25–− 0.13) 0.0001
IDH-mutant_1p/19qret without AB/FS mismatch	0.018 (0–0.022) 0.22	0.069 (0.001–0.086) 0.016	− 0.081 (− 0.13–− 0.01) 0.016

∆3.5 = [3–4 ppm] = 1-ppm frequency range centred on the amide frequency at 3.5 ppm; ∆2 = [1.5–2.5 ppm] = 1-ppm frequency range centred on the amine frequency at 2 ppm; AB-FS = AB − FS models; ratio = amide/amine ratio. p-values in bold represent statistically significant values. Threshold for significance p = 0.05