Figure 8.

Graphical illustration of the interaction between LINC01431 and PRMT1 in repressing HBV cccDNA transcription. In this study, LINC01431 interacts with PRMT1 to block HBx‐mediated ubiquitination and degradation. As a result, LINC01431 increases the occupancy of PRMT1 on cccDNA and catalyzes the H4R3me2a, leading to cccDNA‐bound histones hypoacetylation and cccDNA silencing. In turn, HBx transcriptionally represses LINC01431 expression by targeting ZHX2 to evade host restriction. Collectively, our study presents a novel HBx‐LINC01431‐PRMT1 feedback loop responsible for regulating HBV transcription, which might provide novelty strategies for HBV intervention.