Table 1.

Genes and complexes to be entered as dependent variables in regression analysis and the constituent proteins (genes)

Gene or Complex	Proteins Comprising Complex
NOD2	NOD2
ATG16L1	ATG16L1
CARD9	CARD9
NOD2-RIPK2 complex	RIPK2, NOD2, XIAP, BIRC2, BIRC3, ITCH
TAK1-TAB complex	TAK1, TAB2, TAB3
IRAK-TRAF6 complex	IRAK1, IRAK2, IRAK4, TRAF6, MYD88

All genes’ GenePy scores are scaled to between 0 and 1 and corrected by LOEUF (loss of function observed/expected upper bound fraction) score prior to being summed to form the complex’s GenePy score.