Table 2.
Linear regression results of genes and complexes and the impact on NOD signaling transcription
| Dependent Variable: Gene/Complex GenePy Score | Independent Variable: Quantile-Normalized Gene Expression | β Coefficient | R 2 Value for Linear Regression Model | P Value |
|---|---|---|---|---|
| NOD2 | NOD2 | -0.702 | 0.460 | .000043 |
| NFKBIA | 0.486 | .001 | ||
| CCL5 | -0.414 | .008 | ||
| ATG16L1 | IKBKB | 0.504 | 0.403 | .001 |
| IRAK4 | -0.498 | .001 | ||
| CYBA | -0.288 | .041 | ||
| CARD9 | PYCARD | -0.559 | 0.510 | .0007 |
| IFNB1 | 0.333 | .006 | ||
| TRAF2 | 0.371 | .003 | ||
| TANK | -0.294 | .025 | ||
| NOD2-RIPK2 complex (RIPK2, NOD2, XIAP, BIRC2, BIRC3, ITCH) | BIRC2 | 0.800 | 0.687 | 3.1475 × 10-8 |
| TXN | 0.417 | .000084 | ||
| NLRP3 | 0.245 | .014 | ||
| PYCARD | -0.278 | .014 | ||
| IRAK4 | -0.345 | .001 | ||
| UBA52 | -0.224 | .033 | ||
| TAK1-TAB complex (TAK1, TAB2, TAB3) | MAPK14 | -0.677 | 0.438 | .000017 |
| IFNA1 | 0.479 | .001 | ||
| BIRC3 | -0.375 | .008 | ||
| IRAK-TRAF6 complex (IRAK1, IRAK2, IRAK4, TRAF6, MYD88) | IKBKG | -0.508 | 0.258 | .001 |