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. 2022 May 20;12:837205. doi: 10.3389/fcimb.2022.837205

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Copyright © 2022 Chen, Wu, Zeng, Chen, Li, Li, He and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of FuZhengHuaYuJiangZhuTongLuoFang prescription (FZHY) on renal function in unilateral ureteral obstruction (UUO) rats. Levels of the biochemical parameters including serum creatinine (SCR) (A) and blood urea nitrogen (BUN) (B) were detected in the sham, UUO, UUO+FZHY, and UUO+AST-120 groups on days 7, 14, and 21. The renal tissue injury was detected (C) and scored (D) based on histology (HE staining). The renal tissue fibrosis was detected (E) and the relative fibrotic area was analyzed (F) based on Masson’s trichrome staining; ×400 magnification on days 7, 14, and 21. *P < 0.05, **P < 0.01, ***P < 0.001, the UUO group vs. the sham group; ^# P < 0.05, the UUO+FZHY group vs. the UUO group; ^Δ P < 0.05, ^ΔΔ P < 0.01, the UUO+AST-120 group vs. the FZHY-treated group. ns, not significant.