Table 1.
Clinicopathological Features of EGFR Mutant and EGFR Wild Type Patients Between Training Cohort and Test Cohort
| Clinicopathological Features | Training Cohort | Test Cohort | ||||||
|---|---|---|---|---|---|---|---|---|
| Total (n = 176) | EGFR Mutant (n = 97) | EGFR Wild Type (n = 79) | P value | Total (n = 57) | EGFR Mutant (n = 32) | EGFR Wild Type (n = 25) | P value | |
| Age (Mean ± SD), years | 58.9 ± 10.3 | 59.6 ± 9.3 | 58 ± 11.4 | 0.2896 | 56.1 ± 8.9 | 56.1 ± 9 | 54.3 ± 8.7 | 0.6233 |
| Gender | 0.0014** | 0.033* | ||||||
| Male | 99(56.3) | 44(45.4) | 55(69.6) | 29(50.9) | 12(37.5) | 17(68) | ||
| Female | 77(43.7) | 53(54.6) | 24(30.4) | 28(49.1) | 20(62.5) | 8(32) | ||
| Smoking status | 0.0034** | 0.024* | ||||||
| Never-smoker | 129(73.3) | 80(82.5) | 49(62) | 39(68.4) | 26(81.3) | 13(52) | ||
| Former or current smoker | 47(26.7) | 17(17.5) | 30(38) | 18(31.6) | 6(18.7) | 12(48) | ||
| TNM Staging | 0.3835 | 0.0287* | ||||||
| I | 74(42) | 42(26.7) | 32(26.7) | 33(57.9) | 18(56.3) | 15(60) | ||
| II | 16(9.1) | 9(26.7) | 7(26.7) | 4(7) | 4(12.5) | 0(0) | ||
| III | 20(11.4) | 14(26.7) | 6(26.7) | 7(12.3) | 6(18.7) | 1(4) | ||
| IV | 66(37.5) | 32(26.7) | 34(26.7) | 13(22.8) | 4(12.5) | 9(36) | ||
| Maximum diameter | 0.0099** | >0.9999 | ||||||
| ≥3cm | 59(33.5) | 24(24.7) | 35(44.3) | 12(21.1) | 7(21.9) | 5(20) | ||
| <3cm | 117(66.5) | 73(75.3) | 44(55.7) | 45(78.9) | 25(78.1) | 20(80) | ||
| Location | 0.0546 | 0.2494 | ||||||
| Right upper lobe | 57(32.4) | 40(41.2) | 17(21.5) | 23(40.4) | 17(53.1) | 6(24) | ||
| Right middle lobe | 8(4.5) | 4(4.1) | 4(5.1) | 2(3.5) | 1(3.1) | 1(4) | ||
| Right lower lobe | 32(18.2) | 15(15.5) | 17(21.5) | 11(19.3) | 5(15.6) | 6(24) | ||
| Left upper lobe | 57(32.4) | 29(29.9) | 28(35.4) | 11(19.3) | 4(12.5) | 7(28) | ||
| Left lower lobe | 22(12.5) | 9(9.3) | 13(16.5) | 10(17.5) | 5(15.6) | 5(20) | ||
| Growth pattern | <0.0001*** | 0.0145* | ||||||
| Lepidic | 16(9.1) | 14(14.4) | 2(2.5) | 5(8.8) | 4(12.5) | 1(4) | ||
| Acinar | 90(51.1) | 60(61.9) | 30(38) | 27(47.4) | 15(46.9) | 12(48) | ||
| Papillary | 31(17.6) | 15(15.5) | 16(20.3) | 12(21) | 10(31.2) | 2(8) | ||
| Solid | 39(22.2) | 8(8.2) | 31(39.2) | 13(22.8) | 3(9.4) | 10(40) | ||
Notes: The P value represents the univariate association between each of clinical features and EGFR mutation. Data are presented as n, or n (%), except where otherwise noted. *P<0.05; **P<0.01; ***P<0.0001.