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. Author manuscript; available in PMC: 2022 Jun 4.
Published in final edited form as: Cell Metab. 2021 Oct 21;33(11):2201–2214.e11. doi: 10.1016/j.cmet.2021.10.001

Fig 5. FAPs expressing THY1 (CD90) represent a distinct subpopulation.

Fig 5.

A, UMAP of FAPs with interpolated lineage prediction (n=4, study 2); B, Cell size of MuSCs, FAPCD90− and FAPCD90+ (n=16, study 2, non-T2DM); C, EdU+ of FAPCD90− and FAPCD90+ post FACS (n=9–13, study 2, non-T2DM); D, Limiting dilution assay of FAPCD90− and FAPCD90+ (n=3), solid line is non-linear fit; E+F, % adipogenic or fibrogenic clones from single sorted FAPCD90−/+; G, PCA-plot based on DE genes in FAPCD90− and FAPCD90+ (n=3, study 2, non-T2DM); H+I, Biological processes in FAPCD90− and FAPCD90+, respectively (n=3, study 2, non-T2DM); J+K, Collagen-1 protein expression post sort (n=5, study 2, non-T2DM); L, Work-flow; M, OCR (pmol/min) of MuSCs, FAPCD90− and FAPCD90+ (n=7, study 2, non-T2DM); N, ECAR, (mpH/min) of MuSCs, FAPCD90− and FAPCD90+; O, EACR/OCR ratio of MuSCs, FAPCD90− and FAPCD90+; P, Skeletal muscle IHC of CD34 (Red), CD90 (Cyan) and WGA (green). Blue arrow is CD34+ CD90+, red arrows is CD34+CD90−. Cells from mm. Rectus Abdominus/Gastrocnemius. *p<0.05.