. 2022 Jun 1;26(6):558–565. doi: 10.5588/ijtld.21.0654

Table 4.

Serum hormones and BMI in NC-006

		Baseline		Week 1		Week 2		Week 4		Week 8		Week 12		Week 17		Week 26

		n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	n	Median
FSH	Pa₁₀₀MfxZ, Week 17^*	51	5.9	51	6.5	51	7.7	50	6.4	50	6.8	45	7.1	45	7.9	37	5.9
	Pa₂₀₀MfxZ, Week 17^†	48	6.7	47	8.7	46	8.7	47	9.2	47	8.1	46	7.7	44	7.2	30	7.2
	Pa₂₀₀MfxZ, Week 26^‡	50	6.4	49	7.6	47	8.5	47	9.2	44	6.9	45	6.8	27	6.6	37	6.3
	HRZE, Week 17^§	48	5.4	48	7.1	47	6.8	48	6.8	45	6.4	44	6.4	23	5.8	43	5.6
InhB	Pa₁₀₀MfxZ, Week 17^*	51	117.7	51	109.9	50	117.4	50	134.6	48	137.9	46	137.3	45	130.0	34	129.2
	Pa₂₀₀MfxZ, Week 17^†	48	98.7	47	94.0	46	95.7	48	104.2	48	115.9	46	118.9	45	130.4	28	129.2
	Pa₂₀₀MfxZ, Week 26^‡	50	109.6	48	106.1	47	101.6	47	118.9	43	149.2	47	142.6	27	161.0	38	151.0
	HRZE, Week 17^§	48	123.0	47	110.8	46	123.9	45	129.8	46	146.1	44	152.9	25	155.4	43	153.2
LH	Pa₁₀₀MfxZ, Week 17^*	51	5.7	51	5.5	51	5.0	50	5.1	50	5.4	46	4.6	46	5.7	37	5.0
	Pa₂₀₀MfxZ, Week 17^†	48	5.8	47	6.0	46	5.6	47	6.2	47	5.5	46	5.0	44	5.2	30	5.4
	Pa₂₀₀MfxZ, Week 26^‡	50	6.7	49	6.6	47	5.9	47	6.5	43	5.7	46	5.9	27	5.0	37	5.9
	HRZE, Week 17^§	48	5.6	48	5.3	47	5.8	48	5.7	45	4.6	43	5.6	23	5.2	43	6.0
T	Pa₁₀₀MfxZ, Week 17^*	51	9.5	51	13.5	50	13.9	50	13.2	50	15.9	46	14.5	46	15.1	36	17.8
	Pa₂₀₀MfxZ, Week 17^†	48	9.5	47	12.7	46	12.0	47	11.6	47	12.8	46	13.7	44	15.3	30	17.9
	Pa₂₀₀MfxZ, Week 26^‡	50	10.6	49	15.0	47	12.0	47	14.8	44	15.7	45	17.0	27	15.3	35	18.7
	HRZE, Week 17^§	48	11.5	48	20.0	47	21.7	48	22.6	45	25.5	44	26.6	23	23.2	42	24.8
BMI	Pa₁₀₀MfxZ, Week 17^*	51	18.6	51	18.8	51	18.8	50	19.3	50	19.2	47	19.5	47	19.5	37	19.5
	Pa₂₀₀MfxZ, Week 17^†	48	18.0	47	18.2	46	18.2	48	18.7	48	19.0	47	19.4	45	19.5	30	19.2
	Pa₂₀₀MfxZ, Week 26^‡	50	18.3	49	18.6	47	18.6	46	18.9	44	18.9	48	19.4	27	20.4	38	19.1
	HRZE, Week 17^§	48	18.9	48	18.7	47	19.0	48	19.3	46	19.6	44	20.6	25	20.9	43	20.4

* Pa 100 mg/d for 17 weeks (DS).

† Pa 200 mg/d for 17 weeks (DS).

‡ Pa 200 mg/d for 26 weeks (DR).

§ Standard of care (HRZE/HR).

BMI = body mass index; FSH = follicle stimulating hormone; Pa = pretomanid; Mfx = moxifloxacin; Z = pyrazinamide; H = isoniazid; R = rifampicin; E = ethambutol; inhB = inhibin B; LH = luteinizing hormone; T = (total) testosterone; DS = drug-susceptible; DR = drug-resistant.