Table 3. Change in serum levels of vitamin D and angiogenic marker at 16 weeks follow-up.
| Placebo (n = 59) | Cholecalciferol (n = 58) | Between group difference | ||||
|---|---|---|---|---|---|---|
| Mean change (95% CI) | p value | Mean change (95% CI) | p value | Difference of Mean change (95% CI) | p value | |
| 25(OH)D (ng/ml) | 1.51 (-0.46 to 3.48) | 0.130 | 24.91 (21.77to 28.06) | <0.001 | 23.40 (19.76 to 27.06) | <0.001 |
| 1,25 (OH)2 D (pg/ml) | 0.48 (-4.65 to 5.62) | 0.608 | 15.46 (5.42 to 25.50) | <0.001 | 14.98 (4.48 to 27.18) | 0.001 |
| Ang-1 (ng/ml) | 5.63 (0.51 to 10.75) | 0.020 | 1.36 (-2.39 to 5.11) | 0.280 | -4.27 (-10.56 to 2.01) | 0.445 |
| Ang-2 (ng/ml) | -0.46 (-1.10 to 0.18) | 0.154 | -0.73 (-1.25 to -0.20) | 0.002 | -0.27 (-1.09 to 0.55) | 0.624 |
| VEGF (pg/ml) | 34.11 (-66.11 to 134.35) | 0.592 | 20.77 (-046.68to 88.24) | 0.335 | -13.34 (-133.38 to 106.60) | 0.990 |
| VEGFR (pg/ml) | -87.16 (-131.89 to -42.44) | <0.001 | -69.77 (-142.74 to 3.20) | 0.061 | 17.39 (-67.47 to 102.25) | 0.985 |
| Tie-2 (ng/ml) | 0.14 (-3.28 to 3.55) | 0.686 | 3.70 (-1.95 to 9.36) | 0.427 | 3.56 (-2.98 to 10.12) | 0.366 |
| Ang-1/Ang-2 ratio | 5.5 (1.73 to 9.31) | 0.003 | 2.19 (2.30 to 6.68) | 0.049 | -3.32 (-9.12 to 2.48) | 0.563 |
Data presented as mean change (95% CI).
25(OH)D; 25 hydroxy vitamin D, 1,25 (OH)2 D; 1,25 di-hydroxy vitamin D, Ang-1; Angiopoitein-1, Ang-2; Angiopoitein-2 VEGF; vascular endothelial growth factor-A, VEGFR; vascular endothelial growth factor receptor, Tie 2; tyrosine kinase receptor-2.