Table 2. ELISA binding results to different spike protein variants.
Antibody Description | S1 Binding EC50 ± Std Deviation (ng/mL) | RBD Binding EC50 ± Std Deviation (ng/mL) | S2 Binding EC50 (ng/mL) |
---|---|---|---|
mAb2130 WT | 1.98 ± 0.04 | 2.68 ± 0.94 | ND |
mAb2130 YTE | 15.53 ± 4.731 | 6.76 ± 5.33 | ND |
mAb2130 YTE-LALA | 14.82 ±5.21 | 11.33 ± 2.01 | ND |
mAb2381 WT | 1.50 ± 0.16 | 7.41 ± 0.37 | ND |
mAb2381 YTE | 9.60 ± 2.39 | 8.53 ± 0.43 | ND |
mAb2381 YTE-LALA | 10.73 ± 2.73 | 7.38 ± 1.26 | ND |
mAb2130 + mAb2381 YTE/LALA (ADM03820) | 14.63 ± 2.95 | 7.80 ± 0.39 | ND |
mAb2130 + mAb2381 YTE (ADM03826) | 12.69 ± 3.98 | 10.40 ± 0.52 | ND |
WT: Wild type sequence.
ND: No binding detected.