Table 1.
Interaction between SHP2 and its binding protein in inflammatory diseases
| Protein | Function of SHP2 | Regulated signaling pathway | References |
|---|---|---|---|
| ANT1 | Dephosphorylation | SHP2-ANT1-NLRP3 | 112 |
| TLR7 | Dephosphorylation | SHP2-TLR7- NF-κB | 91 |
| DOK1 | Dephosphorylation | SHP2-DOK1-Uridine | 330 |
| Parkin | Dephosphorylation | SHP2-Parkin- Mitophagy | 38 |
| PD-1 | Dephosphorylation | SHP2-PD-1-M1 polarization | 113 |
| CagA | Activation | CagA-SHP2-IFNγ | 42 |
| p85 | Dephosphorylation | SHP2-p85 | 110 |
| STAT1 | Dephosphorylation or sequestration | SHP2-STAT1-NF-κB | 46,148,331 |
| JAK2 | Dephosphorylation | SHP2-JAK2-STAT3 | 45 |
| RhoA | Dephosphorylation | SHP2-RhoA | 53 |
| D1R | Activation | DIR-SHP2- ERK1/2 | 73 |
| cKit | Interactor | cKit-SHP2- AβPP | 76 |
| Tau | Interactor | Tau-SHP2- NGF Ras-MAPK | 77 |
| Gab1/2 | Dephosphorylation | SHP2-FGF-Gab-MAPK | 61 |
| FGF | Dephosphorylation | SHP2-FGF-Gab-MAPK | 61 |
| EGFR | Dephosphorylation | EGFR-SHP2-Gab | 63 |
| CD31 | Activation | CD31-SHP2-ZAP70 | 97 |
| ZAP70 | Activation | CD31-SHP2-ZAP70 | 97 |
| TBK1 | Adaptor | SHP2-TBK1-Type I IFN | 332 |
| Hook1 | Interactor | SHP2-Hook1-TGF-β-EMT | 333,334 |
| Syntenin | Dephosphorylation | SHP2-sEV biogenesis | 41 |
| p115RhoGEF | Dephosphorylation | SHP2-DC migration | 335 |
| IL22R1 | Dephosphorylation | SHP2-IL22R1-MAPK-STAT3 | 336 |
| ASK1 | Inhibits ubiquitination degradation | SHP2-SOX7-cJun | 337 |
| SIRPalpha | Being sequestered | IL4/IL13 and M2 activation | 47 |